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Glucolipotoxicity:We will identify defects in the regulation of adipose tissue lipid metabolism associated with obesity and diabetes using models with altered expression of hormone sensitive lipase (HSL), the rate-limiting step in lipolysis 39 and phosphodiesterase3B (PDE3B) 40-42, a key enzyme controlling insulin action HSL activity. Altered profiles of lipid derived second messengers and alterat

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/target-tissues - 2025-10-21

New drug targetsWe have in the different sections tested a number of pathways as putative new drug targets including exploring the role of TXNIP for the development of glucotoxicity in β-cells, muscle and kidney and the role of glucokinase in the β-cells. We have also explored the role of Ncf1 in thymus mediated control of tolerance. Potentially, all studied pathways can include regulatory steps w

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/therapy - 2025-10-21

Olle Melander’s group Our researchWhen type 2 diabetes has been determined, a patient’s absolute risk of future cardiovascular disease events remains very high despite available preventive therapies. Thus, primary prevention of diabetes appears instrumental in reducing the population burden of diabetes-related cardiovascular disease. This group focuses on identifying mechanisms causally related to

https://www.ludc.lu.se/research/cardiovascular-research-hypertension - 2025-10-21

Anna Blom’s group Our researchOur group focuses on the complement system, which is part of the immune system. The complement system contains more than 40 proteins that circulate in the blood and these proteins play an important role in the innate defense against pathogens, and in the removal of unwanted materials.Researchers have discovered that complement proteins also have other functions; one e

https://www.ludc.lu.se/research/medical-protein-chemistry - 2025-10-21

Isabel Gonçalves' group Our researchMany victims of heart attacks and stroke die before reaching the hospital. The most frequent cause of myocardial infarction and stroke is the rupture of an atherosclerotic plaque with the subsequent formation of a thrombus that occludes the vessel. The rupture-prone plaques are called vulnerable plaques (VP), and usually have a large lipid and necrotic core, are

https://www.ludc.lu.se/research/cardiovascular-research-translational-studies - 2025-10-21

João Duarte’s group  Our researchThe overall purpose of our research is to understand the molecular determinants underlying cognitive impairment associated with diabetes and metabolic syndrome components, including obesity, dyslipidaemia, hypertension, insulin resistance and hyperglycaemia.Our team is interested in understanding metabolic interactions between glial cells and neurons, how these are

https://www.ludc.lu.se/research/diabetes-and-brain-function - 2025-10-21

The LUDC Early Career Network (LUDC ECN) is an academic network at Lund University Diabetes Centre (LUDC). The network organises events, awards grants, and works as a central hub for young scientists and students at LUDC. The academic network works as a central hub for young scientist, postdoctoral fellows and students at LUDC. The academic network (formerly called DPLU) was formed in 2002 and, si

https://www.ludc.lu.se/ludc-ecn/about - 2025-10-21

Isabella Artner’s group Our researchDiabetes results from loss or dysfunction of insulin producing beta cells in the pancreas. Despite insulin injection treatment, diabetic patients suffer from long-term complications, such as blindness and kidney failure. Therefore, a central goal of diabetes research is to regenerate pancreatic beta cells or produce large numbers of functional beta cells for tra

https://www.ludc.lu.se/research/endocrine-cell-differentiation-and-function - 2025-10-21

Eva Degerman’s group Our researchThere is a confirmed relationship between diabetes and dysfunction of the inner ear, our hearing and balance organ, and a large number of reviews and meta-analyses have been published on the subject. However, the mechanisms behind this association are not known. Our ongoing studies indicate that the inner ear is a direct target for insulin action and insulin resist

https://www.ludc.lu.se/research/insulin-signal-transduction - 2025-10-21

Helena Elding Larsson’s group Our researchThe overall purpose of our research is to investigate etiology, prediction, and prevention of pediatric autoimmune diabetes (type 1 diabetes) and other autoimmune diseases. Type 1 diabetes is preceded by an immune-mediated destruction of the pancreatic islet beta cells resulting in loss of insulin production. Genetic factors confer susceptibility and help

https://www.ludc.lu.se/research/pediatric-endocrinology - 2025-10-21

Here we announce projects with innovation potential. Please contact Innovation Office at LUDC for more information. NCE targeting GPCR 321Anna Andersson and her group at Lund University Diabetes center  have identified a lead compound targeting GPCR 123. The new NCE induces insulin secretion and prevents beta cell apoptosis in vitro. The effects have been confirmed in vivo in a rat model, where ta

https://www.ludc.lu.se/innovation-projects - 2025-10-21

Lena Eliasson’s group Our researchOur research aims to understand the impact of deregulated insulin- and glucagon-secretion from pancreatic islet of Langerhans in the aetiology of type 2 diabetes. We also have an interest in islet cell function in more rare diabetes types, such as cystic fibrosis-related diabetes (CFRD) and glucocorticoid-induced diabetes.The main focus of our research is to inves

https://www.ludc.lu.se/research/diabetes-islet-cell-exocytosis - 2025-10-21

LUDC is a consortium of research groups at Lund University headed by Leif Groop dedicated to unravelling the pathogenesis and treatment of diabetes mellitus. LUDC started July 1st 2006 when selected for funding by the Swedish Research Council (Vetenskapsrådet) in fierce national competition, as a part of the call for applications for Linneaus grants.  What does LUDC do?We are active in several dif

https://www.ludc.lu.se/our-research - 2025-10-21

Paul Franks’s research group Our researchAn assumption that underpins most public health and medicine is that risk profiles and treatment responses of individuals within a target population will approximate the average risk profile for the population. While this will be true for most people, many others deviate from these expectations, such that standard prediction models and interventions are ine

https://www.ludc.lu.se/research/genetic-and-molecular-epidemiology - 2025-10-21

Olga Göransson’s group Our researchProtein phosphorylation is a biological process that regulates most aspects of cellular life, and the enzymes that catalyze this reaction – protein kinases – constitute the largest family of enzymes encoded by the human genome.An overall aim of our research is to study the regulation and function of protein phosphorylation cascades that are important for the main

https://www.ludc.lu.se/research/protein-phosphorylation - 2025-10-21

Cecilia Holm’s group Our researchThe overall purpose of our research is to develop novel strategies for the prevention and treatment of diabetes and related metabolic disorders.Our group works mainly in two different areas. The first area involves the identification and evaluation of a new generation of probiotic bacterial strains that can be used to promote metabolic health. Bacterial strains wit

https://www.ludc.lu.se/research/molecular-endocrinology - 2025-10-21

The LUDC Early Career Network (previously DPLU) awards PhD student grants to ambitious doctoral students with promising projects. Grant recipients are announced at the annual LUDC Diabetes Research Day. An important aim of the student grant is to encourage doctoral students to come up with new research ideas and to train their grant application and research proposal skills. LUDC Early Career Netwo

https://www.ludc.lu.se/ludc-ecn/student-grant - 2025-10-21

The Leif C. Groop Award for Outstanding Diabetes Research is awarded annually by Lund University Diabetes Centre (LUDC) to a young investigator in the field of diabetes research who is active in any of the Nordic countries (Sweden, Denmark, Norway, Finland, Iceland). The prize money of 100,000 SEK is awarded for “scientific excellence that will benefit patients suffering from diabetes”. It may be

https://www.ludc.lu.se/ludc-ecn/leif-c-groop-award - 2025-10-21

Diabetes researcher Leif Groop is globally recognized for his contributions to diabetes research. This scholarship is awarded as a tribute to him. The young scientist scholarship aims to inspire young diabetes researchers to reach for high levels of novelty, quality, impact, and relevance in their scientific work. Lund University annually awards a scholarship of 200,000 SEK, which is intended to s

https://www.ludc.lu.se/ludc-ecn/leif-c-groop-young-scientist-scholarship - 2025-10-21

Early career researchers and doctoral students may benefit from guidance from a mentor, who can act as a positive role model and offer advice on a range of topics from experiments to career paths. Our mentor at LUDC is an experienced researcher who is available to all researchers and doctoral students at the centre. The mentor can share knowledge, act as advisor, and discuss research and career to

https://www.ludc.lu.se/ludc-ecn/mentorship - 2025-10-21